Conformational signals in the C‐terminal domain of methionine adenosyltransferase I/III determine its nucleocytoplasmic distribution
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چکیده
منابع مشابه
Role of Methionine Adenosyltransferase Genes in Hepatocarcinogenesis
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. Detection of HCC can be difficult, as most of the patients who develop this tumor have no symptoms other than those related to their longstanding liver disease. There is an urgent need to understand the molecular mechanisms that are responsible for the development of this disease so that appropriate therapie...
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این پژوهش با هدف "بررسی وضعیت موجود آموزش عالی مجازی در ایران و راههای توسعه و ارتقای آن " و با روش توصیفی-تحلیلی و پیمایشی صورت پذیرفته است. بررسی اسنادو مدارک موجود در زمینه آموزش مجازی نشان داد تعداد دانشجویان و مقاطع تحصیلی و رشته محل های دوره های الکترونیکی چندان مطلوب نبوده و از نظر کیفی نیز وضعیت شاخص خدمات آموزشی اساتید و وضعیت شبکه اینترنت در محیط آموزش مجازی نامطلوب است.
Topology of human methionine S-adenosyltransferase
Insights into the three-dimensional (3D) structure of the enzyme, Methionine S-adenosyltransferase (MAT). can throw light on its role in humans and help in evolving se lectivity attributes of inhibitors targeted at bacterial MAT. We report here a 30model of human MAT, using the X-ray structure of MAT from the rat as a template, by comparative protein modeling principles. The resulting model has...
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چکیده ندارد.
15 صفحه اولChanges in methionine adenosyltransferase during liver regeneration in the rat.
Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes (MAT1A and MAT2A, respectively) that catalyze the formation of S-adenosylmethionine (SAM), the principal methyl donor. We previously showed that MAT2A expression was associated with more rapid cell growth. Here we examined changes in hepatic MAT gene expression and related consequences after two...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.09-130187